The seminal book, Green Chemistry: Theory and Practice, was written by Paul Anastas and John Warner in 1998, and the 12 Principles are one of the cornerstones for an entire community.
The 12 Principles of Green Chemistry
1. Prevention
It is better to prevent waste than to treat or clean up waste after it has been created.
4. Designing Safer Chemicals
Chemical products should be designed to affect their desired function while minimizing their toxicity.
7. Use of Renewable Feedstocks
A raw material or feedstock should be renewable rather than depleting whenever technically and economically practicable.
10. Design for Degradation
Chemical products should be designed so that at the end of their function they break down into innocuous degradation products and do not persist in the environment.
2. Atom Economy
Synthetic methods should be designed to maximize the incorporation of all materials used in the process into the final product.
5. Safer Solvents and Auxiliaries
The use of auxiliary substances (e.g., solvents, separation agents, etc.) should be made unnecessary wherever possible and innocuous when used.
8. Reduce Derivatives
Unnecessary derivatization (use of blocking groups, protection/ deprotection, temporary modification of physical/chemical processes) should be minimized or avoided if possible, because such steps require additional reagents and can generate waste.
11. Real-time Analysis for Pollution Prevention
Analytical methodologies need to be further developed to allow for real-time, in-process monitoring and control prior to the formation of hazardous substances.
3. Less Hazardous Chemical Syntheses
Wherever practicable, synthetic methods should be designed to use and generate substances that possess little or no toxicity to human health and the environment.
6. Design for Energy Efficiency
Energy requirements of chemical processes should be recognized for their environmental and economic impacts and should be minimized. If possible, synthetic methods should be conducted at ambient temperature and pressure.
9. Catalysis
Catalytic reagents (as selective as possible) are superior to stoichiometric reagents.
12. Inherently Safer Chemistry for Accident Prevention
Substances and the form of a substance used in a chemical process should be chosen to minimize the potential for chemical accidents, including releases, explosions, and fires.